What is the Maximum Daily Dosage of Gabapentin?

Author:

I’m taking 800mg three times a day for anxiety. It works great. The max recommended dose is 3600mg daily, but I’ve read where some people take up to 4800mg a day. I guess it depends on the person and how they metabolize it.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

If you are using Gralise® tablets:

  • These should be taken with the evening meal.
  • Swallow the tablet whole. Do not crush, break, or chew it.

For patients with epilepsy who take gabapentin three times per day, do not allow more than 12 hours to pass between any 2 doses. The medicine works best if a constant amount is in the blood.

Neurontin® capsules, tablets, and solution may be taken with or without food.

You may break the scored Neurontin® tablets into two pieces, but make sure you use the second half of the tablet as the next dose. Do not use the half-tablet if the whole tablet has been cut or broken after 28 days. Ask your doctor or pharmacist if you have any questions.

Swallow the capsule whole with plenty of water. Do not open, crush, or chew it.

Measure the oral liquid using a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

If you take an antacid that contains aluminum or magnesium, wait at least 2 hours before taking gabapentin. Some examples of these antacids are Di-Gel®, Gaviscon®, Gelusil®, Maalox® and Mylanta®.

Only use the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (capsules, liquid, and tablets):
    • For epilepsy:
      • Adults and children 12 years of age and older—At first, 300 milligrams (mg) three times per day. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 1800 mg per day (600 mg three times per day).
      • Children 3 to 11 years of age—Dose is based on body weight and must be determined by your doctor. The starting dose is 10 to 15 milligrams (mg) per kilogram (kg) of body weight per day and divided in 3 doses. Your doctor may adjust your dose as needed and tolerated.
      • Children younger than 3 years of age—Use and dose must be determined by your doctor.
    • For postherpetic neuralgia:
      • Adults— At first, 300 milligrams (mg) as a single dose in the evening. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 1800 mg per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

You should store the Neurontin® oral liquid in the refrigerator. Do not freeze.

Although the FDA says 3600mg/day in most places, they have a more extensive doc about gabapentin/neurontin usage and bioavailability. First, your body can only process a certain amount taken and the rest is excreted, so large doses over their bioavailablity chart don’t give larger effects.

Lyrica and other meds have different bioavailability, so use smaller dosages. Since your kidneys do much of the work with gaba/neurontin, you want to make sure you do not have any kidney problems.

A person may need lower doses or not use it due to that. Second, calcium channel meds like gabapentin are nonlinear, so side effects and benefits vary from person to person.

What works or doesn’t work for one, may be the opposite for another. That is why dosage benefits and side effects vary so much from person to person. Even a small dose might make you sleep, but not to another person.

I have heard from some people their doc may prescribe smaller doses during the day and a larger dose at the time of day more problems appear such as at night.

Gaba/neurontin has a short half life so needs doses spread out during the day. One challenging thing is that people that are on gaba are also on other meds too, so there is going to be confusion about what caused what and if there are interactions.

After a couple years, I was only on gaba. For me on maximum dose, I did sleep more, plus several other side effects. It all comes down to finding the most benefit with the least negatives including cost or as docs say, benefits outweigh the risks. Suggest reading more of this forum for a patient viewpoint.